Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CNTF potentiates peripheral nerve regeneration

Z Sahenk1, J Seharaseyon, J R Mendell

  • 1Department of Neurology, Division of Neuromuscular Disease, The Ohio State University, College of Medicine, Columbus 43210.

Brain Research
|August 29, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

β-Sarcoglycan gene transfer decreases fibrosis and restores force in LGMD2E mice.

Gene therapy·2015
Same author

AAV1.NT-3 gene therapy attenuates spontaneous autoimmune peripheral polyneuropathy.

Gene therapy·2015
Same author

The 2-min walk test is sufficient for evaluating walking abilities in sporadic inclusion body myositis.

Neuromuscular disorders : NMD·2013
Same author

Plasmapheresis eliminates the negative impact of AAV antibodies on microdystrophin gene expression following vascular delivery.

Molecular therapy : the journal of the American Society of Gene Therapy·2013
Same author

Lack of toxicity of alpha-sarcoglycan overexpression supports clinical gene transfer trial in LGMD2D.

Neurology·2008
Same author

Orthopedic outcomes of long-term daily corticosteroid treatment in Duchenne muscular dystrophy.

Neurology·2007

Ciliary neurotrophic factor (CNTF) significantly enhances peripheral nerve regeneration in rats. CNTF promotes greater axonal elongation and improved myelination in regenerating nerves.

Area of Science:

  • Neuroscience
  • Regenerative Medicine

Background:

  • Peripheral nerve injury is a significant clinical challenge.
  • Axonal regeneration is crucial for functional recovery after nerve damage.

Purpose of the Study:

  • To investigate the efficacy of ciliary neurotrophic factor (CNTF) in promoting peripheral nerve regeneration.
  • To elucidate the mechanisms by which CNTF influences axonal regrowth.

Main Methods:

  • Sciatic nerve transection model in 6-week-old rats.
  • Intraperitoneal administration of recombinant human CNTF (1 mg/kg every other day for 12 days).
  • Assessment of anterograde axonal transport using [3H]leucine and morphometric analysis.

Main Results:

  • CNTF treatment resulted in a distinct peak of axonal transport activity distally.

Related Experiment Videos

  • Significantly increased retrograde transport from growing axon tips in CNTF-treated rats.
  • Enhanced myelination of regenerating axons observed in CNTF-treated animals.

    • Conclusions:

    • CNTF dramatically potentiates axonal regeneration following peripheral nerve injury.
    • CNTF promotes increased axonal elongation into the distal nerve stump.
    • CNTF supports advanced myelination, indicating improved nerve repair.