[Non-invasive study of cardiovascular function using models of biological age]

In a group of 67 healthy persons (18-60 yrs, mean 37 yrs, male 32, female 35) 77 parameters were investigated (9 physical, 6 biochemical, 3 from ECG, 14 polygraphic, 45 echocardiographic), in 38, ones a significant correlation (Pearson's) with age was found. Biological age or functional cardiovas. age (BA), was calculated using the following formulas: 1.BA = .23BMI- +.11mBP-.43PTT +29.58CO/LVET-.4vPWT-.16FS +15.27h/r, r = 0.980. 2.BA1 = .22mBP +.8AoR-.4vPWT-.19FS +.04iMLV, r = 0.968. BMI--body mass index, mBP--mean blood pressure in Torr, PTT--pulse transmission time (CARi-AII in FCG) in ms, CO/LVET--duration between C-O points in apexcardiogram in ms/left ventricular ejection time (CARu-CARi in carotidogram) in ms ratio, vPWT--velocity of posterior wall thickness of left ventricle in mm.s-1, FS--fractional shortening in %, h/r--2(enddiastolic posterior wall thickness of left ventricle in mm)/enddiastolic diameter of left ventricle in mm ratio, AoR--diameter of the aortic root (mm), iMVL--index of massa of the left ventricle. No significant correlation between heart rate and tests using in formula was found. We found "normal biological age" or cardiovascular function in all groups. But the significant differences between men and women in relative biological age (ca 12% using formula 1, 19% using formula 2, both p < 0.001) were found. (Tab. 3, Ref. 23.)