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Hypothyroxinemia in acquired immune deficiency syndrome (AIDS)
1Department of Radiation Medicine, University of Nigeria Teaching Hospital, Enugu.
Serum thyroxine (T4) and thyroid stimulating hormone (TSH) were studied in 38 patients confirmed to be infected with HIV-1 virus and the results compared with values observed in age matched healthy subjects. The mean serum total T4 in the majority of the patients, 103 +/- 32 nmol/L, was similar to values observed in the controls, 102 +/- 21 nmol/L, p > 0.05. However, 22.2 pc of the HIV-1 infected patients had total serum T4 values that were significantly lower than values in the controls, 36 +/- 12 nmol/L, p < 0.001. Since hypothyroxinemia has been associated with increased mortality in critical illness, we suggest that assessment of thyroid function may be helpful in the management of some patients with AIDS.
Serum thyroxine (T4) and thyroid stimulating hormone (TSH) were studied in 38 patients confirmed to be infected with HIV-1 virus and the results compared with values observed in age matched healthy subjects. The mean serum total T4 in the majority of the patients, 103 +/- 32 nmol/L, was similar to values observed in the controls, 102 +/- 21 nmol/L, p > 0.05. However, 22.2 pc of the HIV-1 infected patients had total serum T4 values that were significantly lower than values in the controls, 36 +/- 12 nmol/L, p < 0.001. Since hypothyroxinemia has been associated with increased mortality in critical illness, we suggest that assessment of thyroid function may be helpful in the management of some patients with AIDS.