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Aspiration complicating bronchopulmonary dysplasia

P J Radford1, P C Stillwell, B Blue

  • 1Phoenix Children's Hospital, Arizona.

Chest
|January 1, 1995
PubMed

Insights

Aspiration is common in infants with bronchopulmonary dysplasia (BPD), contributing to respiratory issues. This study highlights the link between aspiration, identified by the lipid index, and airway abnormalities in BPD patients.

Area of Science:

  • Pediatric Pulmonology
  • Neonatology
  • Respiratory Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease in infants.
  • Respiratory difficulties are common in infants with BPD.
  • The role of aspiration in BPD-related respiratory issues requires further investigation.

Purpose of the Study:

  • To investigate the relationship between aspiration and ongoing respiratory difficulties in infants diagnosed with bronchopulmonary dysplasia (BPD).

Main Methods:

  • Flexible bronchoscopy was performed on 12 infants with BPD.
  • Bronchoalveolar lavage (BAL) was conducted on 11 infants.
  • The lipid index (LI) in BAL fluid quantified aspiration.
  • pH probe studies were performed on seven subjects.

Main Results:

  • A positive lipid index (LI), indicating aspiration, was found in 6 out of 11 subjects.
  • Concordant findings were observed in 5 out of 7 subjects who underwent pH probe studies.
  • Dynamic or structural airway abnormalities were identified in 10 out of 12 infants.

Conclusions:

  • Aspiration is frequently associated with bronchopulmonary dysplasia (BPD).
  • This association exists alongside previously recognized dynamic and structural airway problems.
  • Gastroesophageal reflux and laryngeal injury likely increase aspiration risk in children with BPD.

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