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Characterization and protective effect of a 29 kDa protein isolated from Coxiella burnetii by detergent Empigen BB
M Lukácová1, E Gajdosová, L Skultéty
1Institute of Virology, Slovak Academy of Sciences, Bratislava.
European Journal of Epidemiology
|April 1, 1994
Abstract:
A 29 kDa protein, isolated from the outer membrane of Coxiella burnetii, strain Nine Mile phase I by detergent Empigen BB, was characterized. The failure in removing lipopolysaccharides (LPS) from preparations of the protein by the purification method used indicates a strong binding between proteins and LPS in the outer membrane of C. burnetii. The protein was immunogenic in mice and protected them against virulent C. burnetii challenge.