[Changes in systemic and regional hemodynamics in experimental renal hypertension]

The changes in the cardiac output were studied by the dye-dilution method in rat experiments in different periods of experimentally induced renal hypertension, as well as the distribution of the cardiac output among the tissues and organs. Four days after the procedure a distinct increase of the cardiac output is noted, by the 14th day it returned to the initial level, by the 135th day it clearly tended to decrease. The total peripheral resistance, on the contrary, was steadily growing beginning with the 14th day, thus bringing about an elevation of the arterial pressure. The distribution of the cardiac output among the organs and tissues did not change significantly under hypertensive conditions. The only exception is the cardiac output fraction that is supplied to the spleen.