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The human episome HALF1: structure of its genomic counterpart
C Boccaccio1, J Deschatrette, M Meunier-Rotival
1Unité INSERM 347 affiliée au CNRS, 80, Le Kremlin-Bicêtre, France.
Genetica
|January 1, 1994
Abstract:
A human episomal sequence (HALF1) has been identified by its ability to restore expression of hepatic functions when used to transfect a rat dedifferentiated cell line. The genomic equivalent of this human episome (gHALF1) and its flanking sequences were analyzed. HALF1 itself does not present the characteristics of a transposable element but half of its sequence corresponds to retroposons, including Alu and L1 repeats and a processed pseudogene, known to transpose via RNA intermediates. The structural characteristics of these different kinds of retroposons and their origin and evolution were analyzed.