Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostaglandin-induced neonatal periostitis

M Letts1, E Pang, J Simons

  • 1Division of Orthopaedics, Children's Hospital of Eastern Ontario, University of Ottawa, Canada.

Journal of Pediatric Orthopedics
|November 1, 1994
PubMed
Summary

Prostaglandin treatment for congenital heart defects in infants can cause periostitis, a bone inflammation. This side effect, linked to treatment duration, resolves after discontinuing the medication.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-fused ring A-D-A-type dyes for near-infrared II fluorescence imaging guided phototherapy and immune activation of tumour.

Biochemical and biophysical research communications·2026
Same author

A-D-A-structured phototheranostics for NIR fluorescence imaging guided Type I/II photodynamic and photothermal therapy of tumor.

Nanoscale·2026
Same author

Multifunctional antibacterial intelligent hydrogel for infection detection and inflammation regulation to promote diabetic wound healing.

Biomaterials·2026
Same author

A tirapazamine-assembled phototherapy agent for combined chemotherapy, photodynamic therapy, and photothermal therapy of hepatocellular carcinoma in mice.

Journal of materials chemistry. B·2026
Same author

Spatiotemporally Controlled Antibacterial Therapy via Ultrasound-Activated AIEgens Modulates the Immune Microenvironment to Promote Infected Bone Regeneration.

Advanced healthcare materials·2026
Same author

Long-Lasting Near-Infrared Chemiluminescent Carbon Dots for Deep Tumor Imaging.

Analytical chemistry·2025

Area of Science:

  • Pediatric Cardiology
  • Neonatal Medicine
  • Pediatric Orthopedics

Background:

  • Prostaglandins are crucial for maintaining ductus arteriosus patency in infants with ductal-dependent congenital heart disease.
  • A rare but significant side effect of prostaglandin therapy is symmetrical periostitis of the long bones.

Purpose of the Study:

  • To describe the clinical presentation, onset, and resolution of periostitis in neonates treated with prostaglandins.
  • To investigate the relationship between prostaglandin dosage, duration of treatment, and the development of periostitis.

Main Methods:

  • Retrospective review of neonates with congenital heart disease treated with prostaglandins at a children's hospital.
  • Analysis of clinical data including prostaglandin dosage, infusion duration, onset of symptoms, and radiographic findings.

Related Experiment Videos

Main Results:

  • Five infants developed periostitis, with onset occurring after at least 14 days of prostaglandin infusion.
  • Periostitis was associated with limb pain and extremity swelling, and improved significantly within 6 weeks of discontinuing prostaglandin therapy.
  • The duration of prostaglandin administration appeared to be a more significant factor than dosage in the development of periostitis.

Conclusions:

  • Prostaglandin-induced periostitis is an important consideration in neonates receiving this therapy.
  • Awareness of this condition is crucial for clinical teams and pediatric orthopedists to prevent misdiagnosis and unnecessary investigations.
  • Early recognition and cessation of prostaglandin infusion can lead to resolution of periostitis.