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Exercise reduces age-dependent decrease in platelet protein kinase C activity and translocation

H Y Wang¹, T R Bashore, E Friedman

¹Department of Psychiatry, Medical College of Pennsylvania, Philadelphia.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

|January 1, 1995

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Regular aerobic exercise can help maintain human platelet protein kinase C (PKC) activity and translocation, potentially slowing age-related decline. This enzyme activity may serve as a biological marker for aging.

Area of Science:

Biochemistry
Gerontology
Exercise Physiology

Background:

Investigates the impact of aging and regular aerobic exercise on human platelet protein kinase C (PKC) activity and translocation.
Examines age-related changes in cellular signaling pathways within platelets.

Purpose of the Study:

To determine how age and aerobic exercise influence platelet PKC activity and its cellular localization.
To explore the potential of platelet PKC as a biomarker of aging.

Main Methods:

Collected blood platelets from young (20-36 years) and older (61-78 years) healthy males.
Incubated platelets with phorbol 12-myristate 13-acetate (PMA), 5-HT, or thrombin.
Measured PKC activity in cytosolic and membranous platelet fractions.

Related Experiment Videos

Main Results:

Older non-exercisers showed significantly reduced platelet PKC activity in both cytosol and membrane fractions.
Stimuli-induced redistribution of platelet PKC was diminished in elderly subjects.
Aerobic exercise in older adults partially preserved platelet PKC activity and enzyme redistribution.

Conclusions:

Platelet PKC activity and translocation may serve as biological markers of the aging process.
Regular aerobic exercise can mitigate the age-associated decline in platelet PKC activity and function.
Aerobic fitness may slow the decline in enzyme activation during senescence.