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Related Experiment Videos

Clozapine and urinary incontinence

J P Warner1, C A Harvey, T R Barnes

  • 1Academic Department of Psychiatry, Royal Free Hospital, London, UK.

International Clinical Psychopharmacology
|September 1, 1994
PubMed
Summary

Urinary incontinence can be a side effect of clozapine treatment in patients with severe mental illness. This nocturnal incontinence often occurs early in treatment and resolves spontaneously, but patients may not report it.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Urology

Background:

  • Urinary incontinence is a potential complication in severe mental illness.
  • Both psychosis and neuroleptic medications are implicated, but lack systematic evaluation.
  • Clozapine treatment is known to be associated with incontinence.

Purpose of the Study:

  • To systematically evaluate the relationship between clozapine treatment and urinary incontinence.
  • To determine the incidence and characteristics of incontinence in patients treated with clozapine.

Main Methods:

  • Retrospective assessment of 16 consecutively treated patients.
  • 12 patients were evaluated after excluding one with pre-existing incontinence.
  • Inquiry into the occurrence, timing, and resolution of incontinence.

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Main Results:

  • Nocturnal incontinence occurred in 5 out of 12 patients (41.7%).
  • Incontinence episodes happened within the first 3 months of clozapine treatment.
  • All cases resolved spontaneously.
  • Incontinence was underreported by patients due to embarrassment.
  • Documentation in medical records was poor (1 of 5 cases).

Conclusions:

  • Urinary incontinence is a notable complication of clozapine treatment.
  • It typically presents as nocturnal incontinence early in treatment and resolves spontaneously.
  • Healthcare providers should specifically inquire about incontinence due to patient reluctance to report.
  • Consideration of incontinence is important for managing clozapine compliance.