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Complement component C7 is a plasminogen-binding protein

J Reinartz1, G M Hänsch, M D Kramer

  • 1Institute for Immunology and Serology, University of Heidelberg, Germany.

Journal of Immunology (Baltimore, Md. : 1950)
|January 15, 1995
PubMed
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The complement system component C7 binds plasminogen, enhancing local plasmin generation. This interaction between complement and plasminogen activators may focus tissue damage in antibody-mediated diseases.

Area of Science:

  • Immunology
  • Biochemistry
  • Pathology

Background:

  • Antibody deposition triggers complement activation, leading to tissue damage.
  • Plasmin, a proteolytic enzyme, is implicated in antibody- and complement-mediated organ pathology.
  • Plasminogen activators (PAs) generate plasmin from plasminogen.

Purpose of the Study:

  • To investigate the interaction between the PA system and the complement system.
  • To determine if this interaction promotes local plasmin generation.

Main Methods:

  • Radioligand binding studies to assess plasminogen binding to complement component C7.
  • Investigating the effect of C7 on tissue-type plasminogen activator (tPA)-mediated plasminogen activation.

Main Results:

Related Experiment Videos

  • Complement component C7 binds plasminogen, both in isolation and within the C5b-9 complex.
  • This binding involves the lysine binding sites of plasminogen.
  • C7 enhances tPA-mediated plasminogen activation.

Conclusions:

  • A novel interaction between the complement system and the plasminogen activator system is proposed.
  • This interaction may focus plasmin activity to sites of antibody and complement deposition.
  • This mechanism could contribute to organ pathology in immune-mediated diseases.