Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complex dynamic order in ventricular fibrillation

H Käsmacher-Leidinger1, H Schmid-Schönbein

  • 1Klinik fur Anasthesiologie, Medizinische Einrichtungen der RWTH Aachen, Germany.

Journal of Electrocardiology
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Quantitative and qualitative analysis of the blood flow in breast tumors using power Doppler ultrasound].

Ultraschall in der Medizin (Stuttgart, Germany : 1980)·2008
Same author

Coordination dynamics of circulatory and respiratory rhythms during psychomotor drive reduction.

Autonomic neuroscience : basic & clinical·2004
Same author

[In vivo ICG fluorescence photometry for quantification of warm ischemia damage of to the liver in a rat model].

Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress·2003
Same author

Standardized ultrasound as a new method to induce platelet aggregation: evaluation, influence of lipoproteins and of glycoprotein IIb/IIIa antagonist tirofiban.

European journal of ultrasound : official journal of the European Federation of Societies for Ultrasound in Medicine and Biology·2001
Same author

[Paths to infarction; new findings through in-vivo-rheoscopy].

Der Internist·2001
Same author

Evaluation of hemorheological risk factor profile in plasmacytoma patients.

Clinical hemorheology and microcirculation·2001

This study used a cellular automaton to model ventricular fibrillation, revealing spiral waves and validating findings against electrocardiograms. Modulating refractory periods terminated simulated fibrillation, suggesting therapeutic potential.

Area of Science:

  • Computational biology
  • Cardiac electrophysiology
  • Medical modeling

Background:

  • Self-sustained circus movement of excitation is a leading theory for ventricular fibrillation.
  • Existing mapping studies are costly and limited by external influences.
  • Cellular automata offer a controlled environment for studying excitation dynamics.

Purpose of the Study:

  • To investigate the principles of excitation spreading in ventricular fibrillation using a cellular automaton.
  • To compare model-generated pseudo-electrocardiograms with actual recordings.
  • To explore methods for terminating simulated ventricular fibrillation.

Main Methods:

  • Development and application of a simple cellular automaton model.
  • Simulation of excitation spreading under various conditions.

Related Experiment Videos

  • Analysis of pseudo-electrocardiograms and comparison with clinical data.
  • Modulation of refractory times within the model.

    • Main Results:

    • The model reproduced highly ordered spiral waves, previously interpreted as fibrillation.
    • Simulated electrocardiograms closely matched the time series and Fourier transformations of real recordings.
    • Adjusting refractory periods effectively terminated simulated fibrillation.
    • Findings support the role of autonomic nervous system-induced 1/f variations in protecting against ventricular fibrillation.

    Conclusions:

    • Cellular automata provide a valuable tool for understanding ventricular fibrillation mechanisms.
    • Modulating refractory times shows promise for therapeutic intervention in fibrillation.
    • Autonomic nervous system regulation of heart rate variability may offer protective benefits.