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Evaluation of drug-containing microcapsules

P B Deasy1

  • 1Department of Pharmaceutics, Trinity College, University of Dublin, Ireland.

Journal of Microencapsulation
|September 1, 1994
PubMed
Summary

This review covers drug-loaded microcapsule characterization, focusing on sustained-release oral products. It details assessment methods, including in vitro and in vivo testing, for quality control.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Microcapsules are crucial for sustained-release oral drug delivery.
  • Commercial production often involves pan or air-suspension coating techniques.
  • Understanding microcapsule properties is vital for effective therapeutic outcomes.

Purpose of the Study:

  • To review characterization techniques for drug-loaded microcapsules.
  • To emphasize methods relevant to sustained-release oral formulations.
  • To discuss the correlation between in vitro and in vivo performance.

Main Methods:

  • Optical and spectroscopic evaluation.
  • Particle size analysis.
  • Disintegration, dispersion, and dissolution testing.
  • In vitro and in vivo performance assessments.

Main Results:

  • Various analytical techniques are available for microcapsule characterization.
  • In vitro tests can provide valuable data for predicting in vivo behavior.
  • Core and coating properties significantly influence drug release profiles.

Conclusions:

  • Comprehensive characterization is essential for developing reliable sustained-release microcapsules.
  • A combination of in vitro and in vivo testing ensures product quality and efficacy.
  • Further research into microcapsule formation and assessment technologies is warranted.

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