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Down syndrome and thyroid function in adults

R G Baxter, R G Larkins, F I Martin

    Lancet (London, England)
    |October 25, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Thyroid dysfunction is very common in adults with Down syndrome. This study found clear biochemical evidence of hypothyroidism in most affected individuals, unlike in children with the condition.

    Area of Science:

    • Endocrinology
    • Genetics
    • Gerontology

    Background:

    • Down syndrome is associated with various health complications.
    • Thyroid dysfunction is frequently observed in children with Down syndrome.

    Purpose of the Study:

    • To investigate the prevalence and nature of thyroid dysfunction in middle-aged and elderly adults with Down syndrome.

    Main Methods:

    • Biochemical analysis of thyroid function was performed.
    • 11 middle-aged and elderly subjects with confirmed Down syndrome were included.

    Main Results:

    • 6 out of 11 subjects showed clear biochemical evidence of hypothyroidism.
    • 1 subject presented with biochemical evidence of thyrotoxicosis.

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    Conclusions:

    • Thyroid dysfunction is exceedingly common in adult Down syndrome population.
    • Adults with Down syndrome exhibit a higher prevalence of thyroid dysfunction compared to pediatric cases.