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Renal replacement therapy in cryoglobulinaemic nephritis
A Tarantino1, G Moroni, G Banfi
1Division of Nephrology, Ospedale Maggiore IRCCS, Milano, Italy.
Summary
Patients with nephritis from mixed cryoglobulinaemia undergoing dialysis showed reduced disease signs, with a 5-year survival rate of 65%. While dialysis offers similar life expectancy to other kidney diseases, severe cases have a poorer prognosis.
Area of Science:
- Nephrology
- Immunology
- Renal Medicine
Background:
- Mixed cryoglobulinaemia is a condition causing nephritis.
- Patients often require renal replacement therapy.
Purpose of the Study:
- To evaluate the long-term outcomes of dialysis and kidney transplantation in patients with nephritis due to mixed cryoglobulinaemia.
Main Methods:
- Retrospective analysis of 17 patients with mixed cryoglobulinaemia nephritis undergoing haemodialysis or peritoneal dialysis.
- Follow-up included clinical and immunological assessments.
- Analysis of outcomes after kidney transplantation.
Main Results:
- Dialysis reduced clinical and immunological signs of mixed cryoglobulinaemia in most patients.
- The 5-year actuarial survival rate was 65%.
- Nephritis recurred in both kidney transplant recipients, with one graft lost to chronic rejection.
Conclusions:
- Dialysis provides a comparable life expectancy for mixed cryoglobulinaemia nephritis patients to those with other primary renal diseases.
- Severe initial presentation indicates a poor prognosis.
- Recurrence of nephritis post-transplantation is possible but does not necessarily preclude long-term graft survival.