Immunohistological studies of an oncocytoma

An oncocytoma of the upper eyelid that occurred in an 82-year-old male was studied immunohistologically according to the avidin-biotin-peroxidase complex method (secretory component, carbohydrate antigen 19-9, carcinoembryonic antigen, anticytokeratin AE1/AE3, S-100 protein, myoglobin, actin, vimentin). The staining properties of columnar-type oncocytes were the same as those of epithelial cells of excretory ducts of Moll's gland, but those of polygonal-type oncocytes were similar to those of myoepithelial cells of Moll's gland. Our results suggested that excretory duct epithelial cells of Moll's gland are the origin of oncocytoma of the eyelid.