Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paraneoplastic cerebellar disorders

R W Baloh1

  • 1Department of Neurology, University of California, Los Angeles School of Medicine.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolated dizziness in vertebrobasilar insufficiency: Clinical features, angiography, and follow-up.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Association of benign recurrent vertigo and migraine in 208 patients.

Cephalalgia : an international journal of headache·2009
Same author

Practice parameter: therapies for benign paroxysmal positional vertigo (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.

Neurology·2008
Same author

Otolith dysfunction in vestibular neuritis: recovery pattern and a predictor of symptom recovery.

Neurology·2008
Same author

The relevance of migraine in patients with Meńière's disease.

Acta oto-laryngologica·2007
Same author

Primary episodic ataxias: diagnosis, pathogenesis and treatment.

Brain : a journal of neurology·2007
Same journal

Gender-Affirming Care in Otolaryngology: A State of the Art Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Caffeine Consumption and Rhinologic Symptom Severity.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Ethical Considerations in Using the Pernkopf Atlas in Otolaryngology Education Ethics in Practice: Point-Counterpoint.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Recurrence in HPV-Associated Oropharyngeal Cancer After Transoral Robotic Surgery.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

PEAK-II Trach: A Multi-Institutional Quality Improvement/Simulation Study Assessing Pediatric Emergency Readiness.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Clinical Features, Treatment, and Outcomes for Oropharyngeal Adenoid Cystic Carcinoma: A Systematic Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
See all related articles

Paraneoplastic cerebellar degeneration causes rapid ataxia. Anti-Purkinje cell antibodies, found in women with gynecologic tumors, are specific indicators, though deficits often persist post-treatment.

Area of Science:

  • Neurology
  • Oncology
  • Immunology

Background:

  • Paraneoplastic cerebellar degeneration (PCD) is a rare neurological disorder.
  • It is characterized by rapidly progressive ataxia affecting the trunk and limbs.
  • Antineuronal antibodies are detected in approximately 50% of PCD patients.

Purpose of the Study:

  • To highlight the clinical presentation of PCD.
  • To identify specific autoantibodies associated with PCD.
  • To understand the long-term prognosis of cerebellar deficits in PCD.

Main Methods:

  • Clinical case review.
  • Serological testing for autoantibodies.
  • Correlation of antibody findings with tumor type and patient outcomes.

Related Experiment Videos

Main Results:

  • Rapidly progressive ataxia is the typical onset symptom.
  • Anti-Purkinje cell antibodies are highly specific for PCD, particularly in women with gynecologic malignancies.
  • Cerebellar dysfunction frequently persists even after successful tumor removal.

Conclusions:

  • PCD is a distinct neurological syndrome linked to underlying malignancies.
  • Specific autoantibodies, like anti-Purkinje cell antibodies, aid in diagnosis.
  • The persistent nature of cerebellar deficits underscores the complexity of PCD management.