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Updated: Aug 18, 2026

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears
10:27

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

Published on: February 21, 2018

Histopathologic findings in Menière's disease

P A Wackym1

  • 1Goodhill Ear Center, University of California, Los Angeles School of Medicine 90024-1794.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|January 1, 1995
PubMed

Insights

Meniere

Area of Science:

  • Otolaryngology
  • Inner Ear Disorders
  • Pathology

Background:

  • Meniere's disease etiopathogenesis remains controversial since the early 1900s.
  • Histopathological studies of the inner ear are crucial for understanding Meniere's disease.
  • Previous research has identified several potential pathological mechanisms.

Purpose of the Study:

  • To review the current understanding of Meniere's disease.
  • To discuss the three primary pathological mechanisms implicated in Meniere's disease.
  • To provide a comprehensive overview of the etiopathogenesis of Meniere's disease.

Main Methods:

  • Literature review of histopathological studies.
  • Analysis of research on endolymphatic sac fibrosis.
  • Examination of studies on glycoprotein metabolism and viral infections.

Main Results:

  • Fibrosis of the endolymphatic sac and vestibular epithelia is a key pathological finding.
  • Alterations in glycoprotein metabolism are implicated in Meniere's disease.
  • Inner ear viral infection is a potential contributing factor to the disease.

Conclusions:

  • The etiopathogenesis of Meniere's disease involves complex pathological processes.
  • Understanding these mechanisms is vital for developing effective treatments.
  • Further research is needed to fully elucidate the causes of Meniere's disease.

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