Anti-Candida activity of synthetic hydroxychalcones
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H Tsuchiya1, M Sato, M Akagiri
1Department of Dental Pharmacology, Asahi University School of Dentistry, Gifu, Japan.
Die Pharmazie
|October 1, 1994
Abstract:
The antifungal activity of different synthetic hydroxychalcones was determined against Candida species. It was revealed that the presence of hydroxyl groups at C-2, C-4, and C-2' in chalcone was essential to inhibit Candida growth. Among the chalcone derivatives examined, 2,4,2'-trihydroxy-5'-methylchalcone showed the most intensive anti-Candida activity, suggesting that it could be a potential therapeutic agent for candidosis.