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Spontaneous hemangioendothelial cell hyperplasia of the heart in B6C3F1 female mice
1Division of Pathology, Biosafety Research Center, Foods, Drugs and Pesticides, Shizuoka-ken, Japan.
Insights
Spontaneous hemangioendothelial cell hyperplasia of the heart was observed in female mice during toxicology studies. This rare condition was exclusively found in mice with mammary gland adenocarcinomas.
Area of Science:
- Veterinary Pathology
- Toxicology
- Oncology
Background:
- Spontaneous hemangioendothelial cell hyperplasia is a rare cardiac finding in laboratory animals.
- Understanding its occurrence and characteristics is crucial for interpreting toxicology and carcinogenicity studies.
Purpose of the Study:
- To document and characterize spontaneous hemangioendothelial cell hyperplasia of the heart in B6C3F1 mice.
- To investigate potential associations with other neoplastic conditions.
Main Methods:
- Histopathological examination of cardiac lesions.
- Immunohistochemical staining to identify cell types.
- Lectin-binding patterns and electron microscopy for cellular characterization.
Main Results:
- The condition was identified in 12 out of 3,910 female mice.
- Lesions presented as diffuse, widened vascular spaces lined by hyperplastic hemangioendothelial cells.
- Morphological differences distinguished this hyperplasia from preneoplastic hemangiosarcoma.
- All affected mice also had mammary gland adenocarcinomas.
Conclusions:
- Spontaneous cardiac hemangioendothelial cell hyperplasia is a rare event in this mouse model.
- A notable association exists between this cardiac lesion and mammary gland adenocarcinoma in female mice.
- Further research may elucidate the underlying mechanisms and potential etiological links.
Abstract:
Spontaneous hemangioendothelial cell hyperplasia of the heart was found in 12 of 3,910 female B6C3F1(C57BL/6CrSlc x C3H/HeSlc) mice that were used in chronic toxicology and carcinogenicity studies at the An-Pyo Center (Shizuoka, Japan). Histologically, the lesions appeared diffusely in the heart as widened vascular spaces lined by a single layer of endothelial-like cells with enlarged nuclei between the muscle fibers. These proliferating cells were identified as hemangioendothelial cells by immunohistochemical techniques, lectin-binding patterns, and electron microscopic examination. Morphological differences were found between this spontaneous hemangioendothelial hyperplasia and that which has been reported as a preneoplastic lesions of hemangiosarcoma. Spontaneous hemangioendothelial cell hyperplasia of the heart occurs rarely; however, it was interesting that spontaneous hemangioendothelial cell hyperplasia was only seen in females with adenocarcinomas of the mammary gland.