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Related Experiment Videos

[Reversibility test in obstructive lung disease. Use and limitations]

T J Ringbaek1, P Lange

  • 1Lungemedicinsk afdeling P/lungeklinikken, Bispebjerg Hospital, København.

Ugeskrift for Laeger
|November 28, 1994
PubMed
Summary

Spirometry reversibility tests using bronchodilators and corticosteroids help determine optimal lung function in obstructive airway disease. While statistical significance is defined by specific FEV1 increases, greater improvement is needed for clinical benefit.

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Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Spirometry is a key test for diagnosing and monitoring obstructive airway diseases.
  • Reversibility testing with bronchodilators and corticosteroids is commonly employed to assess airway responsiveness.

Purpose of the Study:

  • To review the performance, utility, and limitations of spirometry reversibility tests.
  • To evaluate the significance of bronchodilator and corticosteroid responses in obstructive airway disease.

Main Methods:

  • Review of existing literature on spirometry reversibility testing.
  • Analysis of established criteria for statistically significant FEV1 improvement after bronchodilator and corticosteroid administration.

Main Results:

  • Statistically significant bronchodilator response defined by FEV1 increase > 0.2 L; corticosteroid response defined by FEV1 increase > 0.35 L.

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  • Higher FEV1 improvements are likely necessary for clinically meaningful benefit.
  • Corticosteroid response is characteristic of asthma, often normalizing lung function or increasing FEV1 > 0.5 L; similar bronchodilator responses occur in some asthmatics.

    • Conclusions:

    • Both bronchodilator and corticosteroid reversibility tests are essential for patients with obstructive airway disease.
    • These tests aid in determining optimal lung function goals for guiding further therapy adjustments.