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Related Experiment Videos

Nickel patch test reactivity and the menstrual cycle

A E Rohold1, L Halkier-Sørensen, K E Andersen

  • 1Department of Dermato-Venereology, Odense University Hospital, Denmark.

Acta Dermato-Venereologica
|September 1, 1994
PubMed
Summary

This study found no change in nickel allergy patch test reactions during the menstrual cycle. However, repeat testing showed increased sensitivity, suggesting a booster effect from initial patch tests.

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Area of Science:

  • Dermatology
  • Immunology
  • Allergology

Background:

  • Premenstrual exacerbation of allergic contact dermatitis is noted.
  • Variations in allergic patch test responses throughout the menstrual cycle have been reported.

Purpose of the Study:

  • To investigate the variation in patch test reactivity to nickel sulfate in nickel-allergic women concerning their menstrual cycle.
  • To determine if nickel patch test sensitivity differs during the premenstrual phase.

Main Methods:

  • Twenty women with nickel allergy and regular periods were enrolled.
  • Patch tests using a dilution series of nickel sulfate were performed on days 7-10 and 20-24 of the menstrual cycle using the TRUE test assay.
  • The threshold concentration of nickel sulfate causing an erythematous reaction was determined, with testing order varied between participants.

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Main Results:

  • No significant difference in patch test reactivity was observed between testing on days 7-10 and days 20-24 (p > 0.4).
  • A significant increase in nickel sensitivity was detected during the second patch test procedure compared to the first (0.02 < p < 0.05), indicating a potential booster effect.
  • The study did not demonstrate increased premenstrual sensitivity to nickel sulfate patch tests.

Conclusions:

  • Increased sensitivity to nickel sulfate patch tests was not observed premenstrually in the studied cohort.
  • Elicitation of positive patch tests resulted in heightened skin reactivity to the same allergen upon subsequent testing weeks later.
  • The findings suggest a booster phenomenon rather than menstrual cycle-related fluctuations in nickel allergy patch test responses.