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Related Experiment Videos

Gender differences in dehydration-induced mitral valve prolapse

S Aufderheide1, D Lax, S J Goldberg

  • 1Department of Pediatrics, University of Arizona Health Sciences Center, Tucson 85724.

American Heart Journal
|January 1, 1995
PubMed
Summary

Dehydration can induce mitral valve prolapse (MVP) in men, but at a much lower rate than in women. This suggests gender and body type influence MVP development due to dehydration.

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Area of Science:

  • Cardiology
  • Physiology

Background:

  • Mitral valve prolapse (MVP) is a common cardiac condition, more prevalent in women.
  • Previous research indicated mild dehydration can induce echocardiographic MVP in asthenic women.

Purpose of the Study:

  • To investigate if dehydration can induce MVP in healthy men.
  • To compare the incidence of dehydration-induced MVP in men versus women.

Main Methods:

  • Ten healthy male volunteers underwent mild diuresis using furosemide (20 mg).
  • Echocardiography assessed cardiac dimensions and function before and after diuresis.
  • Body weight and hydration status were monitored.

Main Results:

  • A significant decrease in weight, left ventricular end-diastolic dimension, and cardiac output was observed in all subjects.

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  • Echocardiographic MVP developed in 1 out of 10 (10%) male subjects.
  • All induced changes resolved upon rehydration.

    • Conclusions:

    • Dehydration-induced MVP occurs infrequently in men without the characteristic body habitus associated with MVP.
    • Gender and body habitus appear to play a significant role in the development of dehydration-induced MVP.