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A linear relationship between ATP degradation and fatigue during high-intensity dynamic exercise in rat skeletal
1Faculty of Human Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands.
Experimental Physiology
|September 1, 1994
Abstract:
The relationship between changes in work output (fatigue) and metabolite concentrations was measured in rat skeletal muscle during the course of dynamic exercise (10 s). After 4 s, work output decreased rapidly to approximately 30% at 8 s. In contrast to the changes in phosphocreatine and lactate, the change in ATP concentration paralleled the reduction in work output. A strong linear relationship (r = 0.95) was found between the relative decrease in ATP and the extent of fatigue. Possible mechanisms underlying this relationship are discussed.