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[Infectious complications after heart surgery]
Abstract:
In the paper the authors report their experience with the prophylaxis and treatment of infectious complications in 393 patients operated upon the heart. An increase of the specific weight of gram-negative bacteria as an etiological cause of infection and also the increase incidence of infection as the main or sole cause of mortality ill patients, operated upon under artifical circulation, were noted. Based on the study of various combinations of antibiotics against principal agents of surgical infection, it was found that a combination of bactericidal drugs such such as ampicillin with gentamycin or carbencillin with gentamycin proved to be the most effective and safe. Tetraolean was shown to be not effective enought against pyocyanic bacillus. Some information concerning the dosage and methods of using various antibiotics and their combinations for prophylaxis and treatment of suppurative complications is reported.
Insights
This study on cardiac surgery patients found gram-negative bacteria increasingly cause infections and mortality. Ampicillin with gentamycin or carbencillin with gentamycin combinations are most effective for preventing and treating surgical site infections.
Area of Science:
- Infectious Diseases
- Cardiovascular Surgery
- Microbiology
Context:
- Focuses on infectious complications in 393 patients undergoing heart surgery.
- Observes a rise in gram-negative bacteria as etiological agents of infection.
- Notes increased mortality attributed to infections in patients on artificial circulation.
Purpose:
- To evaluate the prophylaxis and treatment strategies for infectious complications post-cardiac surgery.
- To identify the most effective antibiotic combinations against common surgical pathogens.
- To report on antibiotic dosages and methods for managing suppurative complications.
Summary:
- Gram-negative bacteria are an increasing cause of infection and mortality in cardiac surgery patients.
- Antibiotic combinations of ampicillin with gentamycin or carbencillin with gentamycin demonstrated high efficacy and safety.
- Tetraolean showed limited effectiveness against Pseudomonas aeruginosa (pyocyanic bacillus).
Impact:
- Provides evidence-based recommendations for antibiotic prophylaxis and treatment in cardiac surgery.
- Highlights the importance of selecting effective antibiotic regimens to combat resistant pathogens.
- Contributes to improving patient outcomes by reducing infectious complications and mortality.