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HLA typing in hairy cell leukemia
L Annino1, A Ferrari, L Laurenti
1Hematology, Dept. of Human Biopathology, University La Sapienza, Rome, Italy.
Leukemia & Lymphoma
|January 1, 1994
Summary
This study found increased frequencies of B17 and DR11 human leukocyte antigen (HLA) antigens in hairy cell leukemia (HCL) patients. DR11 positive patients showed a potentially lower response to interferon (IFN) treatment.
Area of Science:
- Immunogenetics
- Hematology
- Oncology
Background:
- Familial occurrence of hairy cell leukemia (HCL) has been reported without specific HLA associations.
- Previous studies noted an increased frequency of DR11 in non-familial HCL cases.
Purpose of the Study:
- To investigate the association of HLA class I and class II antigens with HCL.
- To explore the correlation between HLA antigen status and clinical characteristics or treatment response in HCL patients.
Main Methods:
- Human leukocyte antigen (HLA) class I and class II typing was performed on 38 consecutive HCL patients.
- Frequencies of HLA antigens were compared to the normal Caucasian population.
- Clinical characteristics and response to interferon (IFN) treatment were analyzed based on DR11 status.
Main Results:
- An increased frequency of HLA-B17 (27%) and HLA-DR11 (57%) was observed in HCL patients compared to controls.
- No significant differences in clinical characteristics were found between DR11 positive and negative patients.
- Complete response (CR) to IFN treatment was achieved in 20% of DR11 positive patients versus 46% of DR11 negative patients.
Conclusions:
- Hairy cell leukemia (HCL) patients exhibit a higher frequency of HLA-B17 and HLA-DR11 antigens.
- HLA-DR11 positive HCL patients may have a reduced response to interferon (IFN) treatment, warranting further investigation in larger cohorts.