Related Experiment Video
Updated: Aug 15, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 24, 2011
Prenatal diagnosis and treatment of congenital adrenal hyperplasia
1Division of Pediatric Endocrinology and Metabolism, North Shore University Hospital, Manhasset, NY 11030.
Abstract:
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is associated with hormonal imbalance which predisposes affected females to prenatal development of genital ambiguity. Because the disease is usually not lethal and can be treated with glucocorticoids, affected pregnancies are seldom terminated. Dexamethasone can be administered to the pregnant mother and is effective in correcting the fetus's adrenal hormone imbalance during gestation. Nearly a decade's experience with prenatal treatment of CAH indicates that the risk-benefit ratio is favorable for mother and fetus with careful medical supervision of gestationally administered dexamethasone.
Related Concept Videos
Smooth Endoplasmic Reticulum
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
Teratogenicity
Diabetes Mellitus: Type 2 and Gestational
Pharmacogenomics: Identification of New Drug Targets
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology

