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Haemostatic factors and prevalent coronary heart disease; the FINRISK Haemostasis Study

V Salomaa1, V Rasi, J Pekkanen

  • 1Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.

European Heart Journal
|October 1, 1994
PubMed

Insights

High levels of lipoprotein (a) and fibrinogen are linked to coronary heart disease (CHD) in adults. These haemostatic factors, along with non-HDL cholesterol, show a significant association with prevalent CHD.

Area of Science:

  • Cardiovascular Medicine
  • Haemostasis Research
  • Epidemiology

Background:

  • Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
  • Understanding the role of haemostatic factors in CHD pathogenesis is crucial for prevention.
  • Previous studies suggest links between clotting factors and cardiovascular events.

Purpose of the Study:

  • To investigate the association between specific haemostatic factors and prevalent coronary heart disease (CHD).
  • To explore potential interactions between haemostatic factors and lipid profiles in relation to CHD.
  • To identify biomarkers for increased risk of prevalent CHD in a population-based cohort.

Main Methods:

  • Cross-sectional analysis of the FINRISK Haemostasis Study cohort.
  • Inclusion of 2365 participants aged 45-64 years.
  • Measurement of plasma fibrinogen, lipoprotein (a) [Lp (a)], factor VII, and plasminogen levels.
  • Statistical adjustment for age, smoking, and lipid profiles.

Main Results:

  • Significantly higher plasma fibrinogen and Lp (a) concentrations were observed in men with prevalent CHD compared to those without.
  • A similar trend for fibrinogen was noted in women, reaching statistical significance.
  • The association of Lp (a) with CHD was dependent on fibrinogen and non-HDL cholesterol levels, indicating interaction effects.

Conclusions:

  • Elevated plasma fibrinogen and Lp (a) are associated with prevalent CHD in the Finnish adult population.
  • These haemostatic factors, particularly in conjunction with high non-HDL cholesterol, may contribute to the development of CHD.
  • While not proving causality, findings highlight the importance of these markers in cardiovascular risk assessment.

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