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On the pathogenesis of IDDM
J Nerup1, T Mandrup-Poulsen, S Helqvist
1Steno Diabetes Center, Gentofte, Denmark.
Diabetologia
|September 1, 1994
Abstract:
A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O2- and nitric oxide) produced by the beta cells themselves. This entire process is under polygenetic control.