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Related Experiment Videos

Spironolactone administration and training-induced hypervolemia

M J Luetkemeier1, K M Flowers, D R Lamb

  • 1Exercise Physiology Laboratory, School of Health, Physical Education, and Recreation, Ohio State University, Columbus 43210.

International Journal of Sports Medicine
|August 1, 1994
PubMed
Summary

Aldosterone significantly contributes to plasma volume expansion during short-term endurance exercise training. Blocking aldosterone with spironolactone reduced exercise-induced plasma volume gains, indicating its crucial role.

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Area of Science:

  • Exercise Physiology
  • Endocrinology

Background:

  • Short-term endurance exercise training leads to plasma volume expansion.
  • The role of aldosterone in this adaptation is not fully understood.

Purpose of the Study:

  • To determine the contribution of aldosterone to plasma volume expansion during short-term exercise training.

Main Methods:

  • Twelve healthy males underwent 3 days of cycling exercise (120 min/day at 65% VO2max).
  • Half received spironolactone to block aldosterone effects.
  • Plasma volume, serum sodium, osmolality, and total protein were measured.

Main Results:

  • Control subjects showed a significant increase in resting plasma volume (501 ml).
  • Spironolactone treatment attenuated plasma volume gains by 67%.

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  • Aldosterone blockade reduced serum sodium and osmolality gains but not total serum protein increase.

    • Conclusions:

    • Aldosterone activity accounts for approximately two-fifths of plasma volume expansion after 3 days of endurance cycling.
    • The remaining expansion is attributed to increased intravascular protein mass.
    • Other neurohormonal factors may also influence plasma volume adaptation to exercise.