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Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
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Latex allergen in respirable particulate air pollution
P B Williams1, M P Buhr, R W Weber
1Allergy Respiratory Institute of Colorado, Denver 80222.
The Journal of Allergy and Clinical Immunology
|January 1, 1995
Summary
Airborne tire fragments in urban pollution contain natural latex antigens. These particles may contribute to increased latex sensitization and asthma, impacting respiratory health.
Area of Science:
- Environmental Science
- Toxicology
- Immunology
Background:
- Urban air contains black particles, potentially tire fragments.
- Natural latex, a tire component, has allergenic properties.
- Latex proteins can act as antigens and adjuvants, posing clinical concerns.
Purpose of the Study:
- To identify and quantify latex antigens in airborne tire fragments.
- To assess the potential health impacts of these particles on respiratory conditions.
Main Methods:
- Collected urban air pollutants using volumetric sampling.
- Characterized particles via microscopy, solubility tests, and mass spectrometry.
- Tested tire fragment extracts for elutable latex antigens using antibody inhibition assays.
Main Results:
- Identified latex in air samples and tire materials using mass spectrometry, microscopy, and solubility tests.
- Confirmed the presence of extractable latex antigens from rubber tire fragments via competitive immunoassay.
Conclusions:
- Latex antigens are present in abundant urban tire fragments.
- Airborne tire particles may contribute to latex sensitization and asthma.
- These particles warrant consideration in respiratory disease and air pollution health impacts.
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