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Related Experiment Videos

Chromium-induced micronuclei in fish

K al-Sabti1, M Franko, B Andrijanic

  • 1Jozef Stefan Institute, Ljubljana, Slovenia.

Journal of Applied Toxicology : JAT
|September 1, 1994
PubMed
Summary
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Chromium (Cr) exposure, both hexavalent (Cr(VI)) and trivalent (Cr(III)), increased micronuclei in Prussian carp erythrocytes. This indicates chromium contamination causes cytogenetic damage in fish, impacting aquatic ecosystems.

Area of Science:

  • Environmental toxicology
  • Aquatic toxicology
  • Genetics

Background:

  • Leather waste discharge introduces chromium (Cr(VI) and Cr(III)) into aquatic environments.
  • Chromium is a heavy metal pollutant with known toxic effects.
  • Prussian carp (Carassius auratus gibelio) are a common freshwater fish species.

Purpose of the Study:

  • To investigate the cytogenetic effects of Cr(VI) and Cr(III) on Prussian carp.
  • To assess chromium-induced genotoxicity in fish erythrocytes.
  • To evaluate chromium contamination in the Ljubljanica River.

Main Methods:

  • Micronuclei induction assay in fish erythrocyte cells was used to detect cytogenetic damage.
  • Fish were sampled from the Ljubljanica River at sites above and below leather waste discharge.

Related Experiment Videos

  • Laboratory experiments involved exposing fish to sub-lethal concentrations of Cr(VI) and Cr(III).

    • Main Results:

    • Exposure to both Cr(VI) and Cr(III) led to a significant increase in micronuclei frequency in fish erythrocytes.
    • Elevated micronuclei levels were observed in fish from both field and laboratory exposure conditions compared to controls.
    • The study confirmed a dose-dependent relationship between chromium concentration and cytogenetic damage.

    Conclusions:

    • Chromium contamination, from sources like leather waste, induces significant cytogenetic damage in Prussian carp.
    • The micronucleus test is a reliable biomarker for assessing chromium genotoxicity in aquatic organisms.
    • Monitoring chromium levels and their effects on fish is crucial for managing riverine ecosystem health.