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Two-generation reproduction study on commercial hexane solvent

W C Daughtrey1, T Neeper-Bradley, J Duffy

  • 1Exxon Biomedical Sciences, E. Millstone, NJ.

Journal of Applied Toxicology : JAT
|September 1, 1994
PubMed
Summary

Commercial hexane vapor inhalation did not affect rat reproduction over two generations. High-level exposure (9000 ppm) reduced offspring body weight gain, but reproductive health remained unaffected. Occupational exposure limits are likely safe.

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Area of Science:

  • Toxicology
  • Reproductive Toxicology
  • Occupational Health

Background:

  • Commercial hexane is used in various industrial applications.
  • Understanding its reproductive toxicity is crucial for worker safety.
  • Previous studies have indicated potential health concerns, necessitating further investigation.

Purpose of the Study:

  • To evaluate the reproductive effects of chronic inhalation exposure to commercial hexane vapors in Sprague-Dawley rats over two generations.
  • To determine if exposure levels relevant to occupational settings pose a reproductive hazard.

Main Methods:

  • Sprague-Dawley rats (males and females) were exposed to 0, 900, 3000, or 9000 ppm of commercial hexane vapor for 6 hours/day, 5-7 days/week, over two generations (F0 and F1 breeding).
  • Exposure continued through mating, gestation, and lactation periods.

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  • Reproductive parameters, litter characteristics, body weight, body weight gain, and histopathology of selected tissues were assessed.

    • Main Results:

    • No significant adverse effects on reproductive parameters (mating, fertility, gestation indices, litter size, postnatal survival) were observed at any exposure concentration.
    • A significant reduction in body weight and body weight gain was noted in F1 and F2 litters exposed to 9000 ppm.
    • Hyaline droplet nephropathy was observed in adult male rats exposed to 9000 ppm, a finding considered not relevant for human health assessment.

    Conclusions:

    • Two-generation inhalation exposure to commercial hexane resulted in reduced body weight gain at 9000 ppm but did not adversely affect reproductive parameters in rats.
    • Current occupational exposure limits for n-hexane and other hexane isomers are unlikely to pose a reproductive hazard to humans.