Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vibration-entrained and premovement activity in monkey primary somatosensory cortex

M A Lebedev1, J M Denton, R J Nelson

  • 1Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis 38163.

Journal of Neurophysiology
|October 1, 1994
PubMed
Summary

Primary somatosensory cortical (SI) neurons show premovement activity (PMA) that may originate centrally. This study found that pre-movement neuronal firing changes, preceding muscle activity, suggest non-peripheral origins for this crucial preparatory brain activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Electroencephalographic predictors of olfactory stimulus discrimination in COVID-19 survivors].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2026
Same author

[Cerebral persistent primitive arteries. Clinical case of combination with intracranial aneurysm and review of the literature].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko·2024
Same author

Interaction of 5-[4'-(<i>N</i>-Methyl-1,3-benzimidazol-2-yl)phenyl]-10,15,20-tri-(<i>N</i>-methyl-3'-pyridyl)porphyrin Triiodide with SARS-CoV-2 Spike Protein.

Russian journal of general chemistry·2022
Same author

Synthesis of Hetaryl-Substituted Asymmetric Porphyrins and Their Affinity to SARS-CoV-2 Helicase.

Russian journal of general chemistry·2021
Same author

Identification of Resistance Genes Effective Against Rice Bacterial Blight Pathogen in Eastern India.

Plant disease·2019
Same author

Management of Potato Late Blight in the Peruvian Highlands: Evaluating the Benefits of Farmer Field Schools and Farmer Participatory Research.

Plant disease·2019

Area of Science:

  • Neuroscience
  • Somatosensory System
  • Motor Control

Background:

  • Primary somatosensory cortical (SI) neurons exhibit premovement activity (PMA) before movement initiation.
  • PMA may arise from central neural processes or peripheral sensory inputs.
  • Understanding PMA's origin is crucial for deciphering motor preparation.

Purpose of the Study:

  • To investigate the temporal characteristics of vibration-entrained SI neuronal discharges during the reaction time period.
  • To determine if changes in these discharges during premovement activity can be attributed to central inputs.

Main Methods:

  • Recorded activity of 55 SI neurons in monkeys during wrist flexion/extension tasks.
  • Stimulated palms with sinusoidal vibration (27, 57, 127 Hz) and analyzed neuronal firing patterns.

Related Experiment Videos

  • Quantified mean firing rate (MFR), mean phase (MP), and synchronicity (Synch) of neuronal responses relative to vibration.

    • Main Results:

    • Observed both increases (activation) and decreases (suppression) in MFR during PMA, often in sequence (2-event PMA).
    • Many pre-EMG MFR shifts preceded electromyographic onset and showed consistent signs for both movement directions.
    • Premovement activation correlated with earlier responses to vibration (shifted MP) and reduced synchronicity, suggesting integration of asynchronous signals.

    Conclusions:

    • Pre-EMG PMA likely originates from central processes, distinct from peripheral reafference.
    • During premovement activation, asynchronous neural signals may integrate with sensory input, influencing neuronal discharge timing and potentially disrupting entrained patterns.