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Related Concept Videos

Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

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Related Experiment Video

Updated: May 11, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

NIH conference. Dopamine- -hydroxylase. Basic and clinical studies

I J Kopin, S Kaufman, H Viveros

    Annals of Internal Medicine
    |August 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Dopamine-beta-hydroxylase, an enzyme crucial for neurotransmitter synthesis, is found in plasma and its levels are influenced by genetics. It serves as an indicator of neurotransmitter release and is linked to certain diseases.

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    Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
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    Related Experiment Videos

    Last Updated: May 11, 2026

    Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
    09:54

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    Published on: August 10, 2012

    Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake
    11:26

    Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake

    Published on: September 21, 2017

    Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
    05:51

    Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

    Published on: October 14, 2021

    Area of Science:

    • Biochemistry
    • Neuroscience
    • Pharmacology

    Background:

    • Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine.
    • DBH is released with catecholamines from the adrenal medulla and sympathetic nerve endings.
    • DBH is a marker for exocytosis, a key neurotransmitter release mechanism.

    Purpose of the Study:

    • To discuss the properties, mechanisms, and distribution of DBH.
    • To explore DBH's role as an indicator of neurotransmitter release.
    • To examine the relationship between DBH levels, genetics, and disease.

    Main Methods:

    • Review of enzyme properties and mechanisms.
    • Description of enzyme distribution.
    • Analysis of plasma DBH levels and their variations.

    Main Results:

    • Plasma DBH levels exhibit significant inter-individual variation, primarily due to genetic factors.
    • Elevated DBH levels are observed in pheochromocytoma patients and decrease post-tumor removal.
    • DBH levels appear normal in hypertensive patients, and their link to disease pathogenesis is unclear.

    Conclusions:

    • DBH is a valuable indicator of exocytosis and neurotransmitter release.
    • Genetic factors significantly influence plasma DBH levels.
    • DBH levels are associated with specific diseases like pheochromocytoma, and DBH inhibition is a pharmacologic tool for psychiatric research.