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[IgD myeloma with skin tumor]
K Kawakami1, T Ishiyama, T Onizuka
1Department of Hematology, Showa University School of Medicine.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|November 1, 1994
Summary
A rare case of IgD multiple myeloma showed skin tumor metastasis after granulocyte colony-stimulating factor (G-CSF) treatment. G-CSF may have contributed to the myeloma cell proliferation and subsequent skin tumor formation.
Area of Science:
- Hematology
- Oncology
- Dermatology
Background:
- A 66-year-old male patient was undergoing treatment for IgD (lambda) multiple myeloma.
- Treatment involved melphalan and prednisolone, followed by management for pneumonia including antibiotics, an antifungal, and granulocyte colony-stimulating factor (G-CSF).
Observation:
- Myeloma cells were detected in peripheral blood 10 days post-second G-CSF administration.
- Skin tumors appeared on the patient's extremities and chest 14 days after the second G-CSF course.
Findings:
- Immunohistochemical analysis confirmed the skin tumors were composed of IgD (lambda)-positive myeloma cells.
- This represents a rare instance of metastasis in multiple myeloma.
- The administration of G-CSF preceded the development of both peripheral blood myeloma cells and skin tumors.
Implications:
- The findings suggest a potential, though rare, link between G-CSF administration and myeloma cell dissemination.
- This case highlights the importance of monitoring for extramedullary disease in multiple myeloma patients, especially after G-CSF therapy.
- Further research is warranted to elucidate the precise mechanisms by which G-CSF might influence myeloma metastasis.