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Haemoglobin-based blood substitutes and sepsis
E Griffiths1, A Cortes, N Gilbert
1National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK.
Abstract:
An important concern that has received little attention is the possible increased susceptibility to bacterial infections of patients infused with cell-free haemoglobin-based blood substitutes. We show that pyridoxalated polymerised human haemoglobin promotes fulminating Escherichia coli septicaemia in mice, which draws attention to the potential danger of such products in the clinic.
Insights
Cell-free hemoglobin blood substitutes may increase susceptibility to bacterial infections. Studies show pyridoxalated polymerized hemoglobin can worsen E. coli infections in mice, indicating potential clinical risks.
Area of Science:
- Biomedical research
- Hematology
- Infectious disease
Background:
- Cell-free hemoglobin (CFH) based blood substitutes are under development.
- A potential risk is increased susceptibility to bacterial infections.
Purpose of the Study:
- To investigate the impact of CFH on bacterial infection susceptibility.
- To assess the safety of pyridoxalated polymerized human hemoglobin (PPHH) in a preclinical model.
Main Methods:
- Mice were infused with PPHH.
- Mice were subsequently infected with Escherichia coli.
Main Results:
- PPHH infusion promoted fulminating E. coli septicemia in mice.
- Significant increase in mortality and disease severity was observed.
Conclusions:
- PPHH may enhance susceptibility to bacterial infections.
- These findings highlight potential dangers of CFH products in clinical settings.