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Haemoglobin-based blood substitutes and sepsis
E Griffiths1, A Cortes, N Gilbert
1National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK.
Lancet (London, England)
|January 21, 1995
Summary
Cell-free hemoglobin blood substitutes may increase susceptibility to bacterial infections. Studies show pyridoxalated polymerized hemoglobin can worsen E. coli infections in mice, indicating potential clinical risks.
Area of Science:
- Biomedical research
- Hematology
- Infectious disease
Background:
- Cell-free hemoglobin (CFH) based blood substitutes are under development.
- A potential risk is increased susceptibility to bacterial infections.
Purpose of the Study:
- To investigate the impact of CFH on bacterial infection susceptibility.
- To assess the safety of pyridoxalated polymerized human hemoglobin (PPHH) in a preclinical model.
Main Methods:
- Mice were infused with PPHH.
- Mice were subsequently infected with Escherichia coli.
Main Results:
- PPHH infusion promoted fulminating E. coli septicemia in mice.
- Significant increase in mortality and disease severity was observed.
Conclusions:
- PPHH may enhance susceptibility to bacterial infections.
- These findings highlight potential dangers of CFH products in clinical settings.