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Related Experiment Videos

Sympathetic skin response (SSR) is abnormal in multiple sclerosis

B Elie1, J P Louboutin

  • 1Laboratoire d'Explorations Fonctionnelles, Hôpital G.R. Laënnec, Nantes, France.

Muscle & Nerve
|February 1, 1995
PubMed
Summary

Sympathetic skin response (SSR) effectively detects autonomic nervous system dysfunction in multiple sclerosis (MS) patients. This simple test reveals widespread sudomotor abnormalities, aiding in MS diagnosis and management.

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Area of Science:

  • Neuroscience
  • Clinical Electrophysiology

Background:

  • Autonomic nervous system dysfunction is common in multiple sclerosis (MS).
  • Standardized tests are crucial for detecting cardiovascular autonomic abnormalities in MS.
  • Sympathetic skin response (SSR) assesses sudomotor sympathetic efferent fiber activity.

Purpose of the Study:

  • To evaluate the utility of SSR in detecting autonomic dysfunction in MS patients.
  • To compare SSR abnormalities with other evoked potentials in MS diagnosis.

Main Methods:

  • SSR was performed on 70 MS patients across different diagnostic categories.
  • Pattern reversal visually evoked potentials, brainstem auditory evoked potentials, and somatosensory evoked potentials were also recorded.
  • SSR parameters including latency and response presence were analyzed.

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Main Results:

  • SSR was abnormal in 94.2% of MS patients.
  • Abnormalities included delayed foot and/or hand latencies and absent responses.
  • Pathological SSR findings were more prevalent than other evoked potential abnormalities in suspected and probable MS.

Conclusions:

  • SSR is a simple and effective method for assessing sympathetic sudomotor outflow disturbances in MS.
  • SSR serves as a valuable addition to existing electrophysiological procedures for MS lesion detection.