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Updated: Aug 15, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
Published on: August 3, 2018
Transforming growth factor-beta-2 (TGF-beta 2) is associated with mature rat neuromuscular junctions
1Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand.
Abstract:
The localisation of transforming growth factor-beta-2 (TGF-beta 2) in skeletal muscles was investigated with immunohistochemistry. In neonates, TGF-beta 2 was distributed throughout the muscle fibres but as the fibres matured TGF-beta 2 became restricted to the circumference of a small subpopulation of nuclei. These nuclei were judged to be the subsynaptic nuclei as they lay beneath the plasmalemma and were associated with alpha-bungarotoxin-labelled neuromuscular junctions. These observations point to TGF-beta 2 being either a trophic factor for mature motoneurones or an autocrine regulator of synaptic protein production.
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