[Protective effect of a beta-1,3-carboxymethylglucan in acute massive blood loss]

Experiments were performed on CBA mice to study the effect of intravenous injections of beta-1,3-f-carboxymethylglucan (Bratislava, Slovakia) during acute massive blood loss (50% of the total blood volume). Two different fractions were used in doses of 25 mg/kg of body weight. The first fraction (semisoluble, its molecular weight being about 10(6)) was shown to have a potent protective effect when it was injected 24 h before blood loss. On the contrary, the other fraction (water soluble, its molecular weight being less than 1.2 x 10(6)) showed no protective effect. Moreover, injection of this fraction 72 h before blood loss can lead to increases in deaths among the mice.