Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The physiologic basis for nonconventional vascular perfusion

L S Nichter1, M A Jazayeri

  • 1Division of Plastic and Reconstructive Surgery, University of Southern California School of Medicine.

Plastic and Reconstructive Surgery
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraneural perineurioma involving the median nerve.

Plastic and reconstructive surgery·2000
Same author

Moebius syndrome: the new finding of hypertrophy of the coronoid process.

The Journal of craniofacial surgery·1999
Same author

Omental transfer to the brain: an experimental study in hydrocephalic rabbits.

Annals of plastic surgery·1999
Same author

The molecular basis of keloid and hypertrophic scar formation.

Molecular medicine today·1998
Same author

Elevated levels of plasminogen activator inhibitor-1 may account for the altered fibrinolysis by keloid fibroblasts.

The Journal of investigative dermatology·1996
Same author

The effects of alloplastic implant onlays on bone in the rabbit mandible.

Plastic and reconstructive surgery·1995

Oxygen and carbon dioxide exchange extend beyond capillaries, occurring in arterioles and venules. This precapillary and postcapillary diffusion is vital for understanding unconventional vascular perfusion techniques.

Area of Science:

  • Physiology
  • Vascular Biology
  • Gas Exchange

Background:

  • Traditionally, oxygen exchange was believed to be limited to capillaries, requiring both arterial inflow and venous outflow.
  • However, research since 1970 suggests significant arteriolar and venular diffusion of oxygen (O2) and carbon dioxide (CO2).

Purpose of the Study:

  • To explore the significance of precapillary and postcapillary diffusion of O2 and CO2.
  • To understand the role of the Bohr effect in regulating this diffusion.
  • To elucidate the success of nonconventional vascular perfusion methods that bypass capillary circulation.

Main Methods:

  • Review of existing studies on arteriolar and venular gas diffusion.
  • Analysis of physiological mechanisms in nonconventional vascular perfusion.

Related Experiment Videos

  • Examination of retrograde "reverse-flow" island flaps and venous flow reversal.

    • Main Results:

    • Significant O2 and CO2 diffusion occurs in arterioles and venules, not just capillaries.
    • Precapillary and postcapillary diffusion, potentially regulated by the Bohr effect, is crucial for unconventional perfusion.
    • Venous flow reversal in specific flap models is attributed to valvular insufficiency and venae comitantes bypass channels.

    Conclusions:

    • Gas exchange is not exclusive to capillaries; arteriolar and venular diffusion plays a key role.
    • Understanding precapillary and postcapillary diffusion is essential for advancing vascular perfusion strategies.
    • Venous flow dynamics in certain surgical contexts involve complex mechanisms beyond simple unidirectional flow.