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Related Experiment Videos

Risk factors in Klippel-Feil syndrome

P D Pizzutillo1, M Woods, L Nicholson

  • 1Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.

Spine
|September 15, 1994
PubMed
Summary

Patients with Klippel-Feil syndrome exhibit altered cervical spine motion, with increased upper segment mobility posing neurologic risks and decreased lower segment motion potentially leading to degenerative disease.

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Area of Science:

  • Orthopedics
  • Neurology
  • Biomechanical analysis of the cervical spine

Background:

  • Klippel-Feil syndrome is associated with significant neurologic deficits.
  • Previous research has not kinematically evaluated cervical spine motion in Klippel-Feil syndrome using control groups and published standards.

Purpose of the Study:

  • To kinematically evaluate cervical spine motion in patients with Klippel-Feil syndrome.
  • To compare cervical spine motion in Klippel-Feil syndrome patients to normal controls and published standards.
  • To identify potential risks associated with altered cervical spine motion in Klippel-Feil syndrome.

Main Methods:

  • Kinematic evaluation of lateral flexion-extension radiographs of the cervical spine.
  • Inclusion of 111 patients diagnosed with Klippel-Feil syndrome.

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  • Comparison of motion in Klippel-Feil patients against a control group and established standards.

    • Main Results:

    • Significantly increased motion per open interspace in the upper cervical segment of Klippel-Feil patients compared to controls.
    • Significantly decreased total motion in the lower cervical segment of Klippel-Feil patients compared to controls.
    • No significant difference in lower segment motion per open interspace between groups.

    Conclusions:

    • Hypermobility of the upper cervical segment in Klippel-Feil syndrome patients indicates a risk for neurologic sequelae.
    • Alterations in lower cervical segment motion in Klippel-Feil syndrome patients may predispose them to degenerative disease.