Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Likelihood methods for locating disease genes in nonequilibrium populations

N L Kaplan1, W G Hill, B S Weir

  • 1Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

American Journal of Human Genetics
|January 1, 1995
PubMed
Summary

This study introduces a new method using Poisson branching processes to map recently emerged disease genes by analyzing their early growth phase. This approach improves genetic mapping accuracy for diseases originating in recent generations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global diversity analysis of plant-associated <i>Pseudopithomyces</i> fungi reveals a new species producing the toxin associated with facial eczema in livestock: <i>Pseudopithomyces toxicarius sp. nov</i>.

Studies in mycology·2026
Same author

<i>Fusarium</i>: more than a node or a foot-shaped basal cell.

Studies in mycology·2021
Same author

Contributions to quantitative genetic models by Yule and by Weinberg prior to Fisher 1918.

Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie·2018
Same author

Phylogenetic relationships of eight new <i>Dacrymycetes</i> collected from New Zealand.

Persoonia·2017
Same author

Fungal Planet description sheets: 558-624.

Persoonia·2017
Same author

ESTIMATION OF GENE FLOW FROM F-STATISTICS.

Evolution; international journal of organic evolution·2017

Area of Science:

  • Population genetics
  • Genetic epidemiology
  • Statistical genetics

Background:

  • Traditional gene mapping relies on linkage disequilibrium (LD) in equilibrium populations.
  • Existing LD methods face challenges due to large variances and assumptions of population equilibrium.
  • Many diseases are recent, making equilibrium assumptions inappropriate for accurate gene mapping.

Purpose of the Study:

  • To develop a novel method for mapping disease genes based on their early growth phase.
  • To estimate the recombination fraction between marker and disease loci for recent diseases.
  • To provide a more accurate approach for genetic mapping of recently emerged genetic disorders.

Main Methods:

  • Utilizing a Poisson branching process model to simulate the early growth of diseases.

Related Experiment Videos

  • Estimating the likelihood of the recombination fraction between marker and disease loci.
  • Analyzing simulated disease populations to validate the new method.

    • Main Results:

    • The method's support interval limits for the recombination fraction are inversely related to disease age in generations.
    • The approach is demonstrated as appropriate for cystic fibrosis and diastrophic dysplasia.
    • The method is shown to be less suitable for Friedreich ataxia and Huntington disease.

    Conclusions:

    • A Poisson branching process model offers a powerful tool for mapping recently emerged disease genes.
    • The method's accuracy is dependent on the disease's age and evolutionary history.
    • The approach allows for comparing the likelihood of different orders of disease and marker loci.