[Age and the functional activity of the pancreatic insular apparatus]

A study was made of age peculiarities of the insular function of the pancreas and of the indices of insuline provision of the organism in rat under conditions of sugar loading. It was shown that, in spite of hyperinsulinemia and a higher rate of insuline release glucose release in old rats became worse; this testified to the development of a relative insuline insufficiency in animals of old age. Hyperinsulinemia in old rats coursed against the background of a decreased total blood insular activity and increased "factor of insulin inactivation". The development of a relative insuline insufficiency in old rats depended on both the insular and the non-pancreatic factors, leading to a decrease of the biological activity of insuline.