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Related Experiment Videos

Plasma TGF beta in systemic sclerosis: a cross-sectional study

N Snowden1, B Coupes, A Herrick

  • 1Department of Immunology, St Mary's Hospital, Manchester.

Annals of the Rheumatic Diseases
|November 1, 1994
PubMed
Summary

Transforming growth factor beta 1 (TGF beta 1) was detected in the plasma of some systemic sclerosis patients, suggesting a potential role in disease pathogenesis. Further longitudinal studies are needed to clarify this relationship.

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Area of Science:

  • Rheumatology
  • Immunology
  • Biochemistry

Background:

  • Systemic sclerosis is a fibrotic disease with unknown pathogenesis.
  • Transforming growth factor beta (TGF beta) is a fibrogenic cytokine implicated in fibrosis.
  • The active 25 kDa form of TGF beta has not been extensively studied in systemic sclerosis plasma.

Purpose of the Study:

  • To detect the active 25 kDa form of TGF beta in systemic sclerosis patient plasma.
  • To investigate the correlation between plasma TGF beta levels and clinical disease severity.
  • To examine the relationship between plasma TGF beta and serum PIIINP levels, a marker of fibrosis.

Main Methods:

  • Cross-sectional study of 39 systemic sclerosis patients, 9 primary Raynaud's disease patients, and 60 healthy controls.

Related Experiment Videos

  • Plasma TGF beta 1 and TGF beta 2 measured using enzyme-linked immunosorbent assay (ELISA).
  • Serum aminoterminal peptide of type III procollagen (PIIINP) measured by radioimmunoassay.

    • Main Results:

    • Active TGF beta 1 was detected in the plasma of 6 out of 39 systemic sclerosis patients.
    • TGF beta 1 was not detected in primary Raynaud's disease patients or healthy controls.
    • No significant correlation was found between plasma TGF beta 1 levels, clinical features, or PIIINP concentrations.

    Conclusions:

    • The 25 kDa form of TGF beta 1 is detectable in the plasma of some systemic sclerosis patients.
    • This finding offers limited support for TGF beta 1's role in systemic sclerosis pathogenesis.
    • Longitudinal studies, especially in early diffuse disease, are necessary to elucidate the relationship between circulating TGF beta 1 and disease activity.