[Effect of H-ATPase stimulators on cyclosporin biosynthesis]

An analogy was observed between the mechanisms of action of phytohormones on plant cells and cells of the fungus producing cyclosporine. Fusicoccin and cytokinin were shown to have a high stimulating action on the biosynthesis of cyclosporine. The stimulating concentrations of the phytohormones and the time of their maximum effect were determined. The electron microscopic studies demonstrated that an increase in the level of the cyclosporine synthesis correlated with a significant increase in the number of the cells in the state of the coagulation necrosis.