Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxic radiosensitizers: substituted styryl derivatives

A Nudelman1, E Falb, Y Odesa

  • 1Chemistry Department, Bar Ilan University, Ramat Gan, Israel.

Archiv Der Pharmazie
|October 1, 1994
PubMed
Summary

Novel styryl epoxides show selective hypoxic radiosensitizing activity, acting as potential alternatives to nitroimidazoles. The styryl group

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indoline-3-propionate and 3-aminopropyl carbamates reduce lung injury and pro-inflammatory cytokines induced in mice by LPS.

British journal of pharmacology·2014
Same author

Changes in the eating habits of ethiopian adolescent immigrants.

International journal of adolescent medicine and health·2012
Same author

The long and narrow bridge: health education for ethiopian adolescent immigrants in youth villages in Israel 1986 - 1998.

International journal of adolescent medicine and health·2012
Same author

A multifunctional 5-aminolevulinic acid derivative induces erythroid differentiation of K562 human erythroleukemic cells.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2012
Same author

A histone deacetylase inhibitory prodrug - butyroyloxymethyl diethyl phosphate - protects the heart and cardiomyocytes against ischemia injury.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2012
Same author

Butyrate-induced differentiation in leukemic myeloid cells - in-vitro and in-vivo studies.

International journal of oncology·2011

Area of Science:

  • Medicinal Chemistry
  • Radiation Oncology
  • Drug Discovery

Background:

  • Radiosensitizers enhance the efficacy of radiation therapy, particularly in hypoxic tumor environments.
  • Existing radiosensitizers like pimonidazole and etanidazole are often based on nitroimidazole structures.
  • Hypoxia (low oxygen) in tumors reduces the effectiveness of radiation therapy.

Purpose of the Study:

  • To synthesize and evaluate novel styryl-based compounds as potential hypoxic radiosensitizers.
  • To explore the bioisosteric relationship between styryl and nitroimidazolyl functionalities.
  • To identify potent radiosensitizing agents with improved properties.

Main Methods:

  • Synthesis of novel styryl epoxides, N-substituted-styryl-ethanolamines, and N,N'-bis-(2-hydroxyethyl)-cinnamamides.
  • Assessment of radiosensitizing activity under hypoxic conditions.
  • Determination of sensitizer enhancement ratio (SER) compared to a known radiosensitizer.

Main Results:

  • Several novel styryl derivatives exhibited selective hypoxic radiosensitizing activity.
  • The styryl group, particularly with electron-withdrawing substituents, was bioisosteric to the nitroimidazolyl group.
  • The compound 2-(2'-nitrophenyl)ethen-1-yl-oxirane (8a) showed a significant SER of 5 relative to misonidazole.

Conclusions:

  • Novel styryl compounds are effective hypoxic radiosensitizers.
  • The styryl moiety represents a promising alternative to nitroimidazoles in radiosensitizer design.
  • Compound 8a demonstrates potent radiosensitizing potential for further investigation.

Related Experiment Videos