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A fibroblast elongation factor purified from colon carcinoma cells shares sequence identity with TIMP-1
M V Agrez1, C J Meldrum, A T Sim
1Faculty of Medicine, University of Newcastle, N.S.W., Australia.
Biochemical and Biophysical Research Communications
|January 17, 1995
Abstract:
We have previously reported that human colon cancer cells secrete a factor(s) which induces elongation of colon fibroblasts in vitro. Isolation of this factor led to the identification of a 55kD protein with fibroblast stretching activity. Two internal amino acid sequences identified in this protein (YEI; GFQALGDAADI) share complete homology with tissue inhibitor of metalloproteinase (TIMP-1).