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Related Experiment Videos

Mechanical circulatory support in children

S A Scheinin1, B Radovancevic, S M Parnis

  • 1Division of Cardiopulmonary Transplantation, Texas Heart Institute, Houston 77225-0345.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|January 1, 1994
PubMed
Summary

Mechanical circulatory support is a feasible option for children with severe heart failure, including those with cardiac allograft rejection or post-cardiotomy shock. Most pediatric patients successfully weaned off support, with survivors leading active lives.

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Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Surgery
  • Biomedical Engineering

Background:

  • Pediatric patients with end-stage heart failure or acute circulatory compromise often face limited treatment options.
  • Mechanical circulatory support (MCS) devices offer a potential lifeline for these critically ill children.
  • Previous experience with MCS in pediatric populations, particularly for diverse indications, is crucial for guiding clinical practice.

Purpose of the Study:

  • To evaluate the feasibility and outcomes of using mechanical circulatory support devices in pediatric patients with profound circulatory failure.
  • To assess the safety, efficacy, and long-term results of MCS in children across various etiologies.
  • To determine the potential for native ventricular recovery and successful weaning from mechanical support.

Main Methods:

Related Experiment Videos

  • Retrospective analysis of nine pediatric patients (1.2-15 years) treated with MCS devices.
  • Indications included acute cardiac allograft rejection, postcardiotomy cardiogenic shock, and bridge to transplantation.
  • Devices used included BioMedicus centrifugal pumps and Hemopump axial flow devices; support duration and flow indices were recorded.

Main Results:

  • Seven out of nine patients were successfully weaned from mechanical circulatory support.
  • Two hospital deaths occurred post-discontinuation due to respiratory failure and sepsis.
  • Surviving patients showed normal hemodynamic indices at discharge and remained free of long-term device-related sequelae at a mean follow-up of 28.8 months.

Conclusions:

  • Mechanical circulatory support is a viable and effective treatment option for children experiencing severe circulatory failure from various causes.
  • Successful weaning and recovery of native cardiac function are achievable in a significant proportion of pediatric patients.
  • Long-term outcomes for survivors are positive, with a return to active, unrestricted lives and no significant device-related complications.